Fig. 1
From: Downregulation of metallothionein-2 contributes to oxaliplatin-induced neuropathic pain
Downregulation of MT2 in spinal dorsal horn neurons is associated with Oxal-induced neuropathic pain. Male rats were treated with vehicle or Oxal (0.4 mg/100 g/day for five consecutive days). a Hind paw withdrawal threshold response to von Frey filament stimuli on days 0, 4, 7, and 10 after the treatment. **p < 0.01 versus vehicle, n = 8. b–e Expression of MT2 in the L4–L6 spinal dorsal horn 10 days after the treatment. *p < 0.05, n = 4. b Transcriptional levels of MT2. c Translational levels of MT2. d Immunostaining for MT2. Scale bar, 100 μm. e Double immunostaining for MT2 (red) with NeuN (neuron marker, green), GFAP (astrocyte marker, green), or Iba1 (microglia marker, green). Scale bar, 50 μm. Oxal, oxaliplatin