Fig. 7

mRNA-profile of the cerebellum. a The transcriptome analysis illustrates the mRNA levels of several surface cell markers, pro-/antiinflammatory markers, and complement components of the cerebellum of GF-IL23 and WT mice at d22 and d33 after induction of the EAE. b The mRNA levels of targets involved in Th17 and Th1 cell signaling are listed from MOG-immunized mice at d22 and d33 in relation to WT immunized with *p < 0.05. c To generate functional categories of upregulated mRNA levels, targets from the data set that met the log2 fold change >1 cutoff and an p value < 0.05 were uploaded to the Database for Annotation, Visualization and Integrated Discovery (DAVID) and relevant categories of cellular functions and pathways were depicted. The number of targets from the data set that map to the category is displayed. Only significant categories with p <0.05 were displayed. In black, the signaling pathways associated with B cells are depicted. Data were generated from naïve GF-IL23, n=6, MOG-immunized GF-IL23/WT mice, n=4. CD cluster of differentiation, CCL chemokine (C–C motif) ligand, CCR C–C chemokine receptor type, CXCL chemokine (C–X–C motif) ligand, H2-Eb1 histocompatibility 2, class II antigen E beta, ICAM-1 intercellular adhesion molecule 1, IFNγ interferon gamma, IL interleukin, Foxp3 forkhead box P3, C1-8 complement component 1-8, CFH complement component factor H, Stat signal transducer and activator of transcription, Rorc RAR-related orphan receptor C, T bet T box expressed in T cells