Fig. 2

Declination of CC nerve fibers CAP by system LPS and inverted by minocycline. a LPS highly significantly downshifted the I/O curve of CC fibers CAP, revealed by AUC (areas under the curves) measurement and analysis, comparing to the I/O curve constructed in saline group (N = 4 in both saline and LPS groups; p < 0.01, shown as **). b Minocycline significantly reversed the system LPS-induced CAP declination also indicated by comparison of AUC between groups (N = 4 in both saline and LPS groups, N = 8 at LPS + minocycline cases; p < 0.05, shown as ^ϯ), suggesting a prevention of minocycline for white matter tract from system LPS induced malfunction