Fig. 3

System LPS induced increment of β-APP, iNOS, and TNF-α, and minocycline inhibited their protein upgrading. a Accumulation of β-APP in the CC tissue reflected by a highly significantly higher level of protein in the LPS group than in the saline group (N = 4; p < 0.01, shown as **). Minocycline evidently reversed this accumulation but did not reach a significant level. b iNOS density in the CC of LPS group was highly significantly enhanced compared to that in the saline group (N = 4; p < 0.01, shown as **); also, minocycline significantly reversed high level of iNOS evoked by system LPS (N = 4; p < 0.05, shown as *). c Similarly, the CC TNF-α level in the LPS group was significantly higher than that in saline cases (N = 4; p < 0.05, shown as *); while minocycline significantly inhibited TNF-α upgrading (N = 4; p < 0.05, shown as *)