Fig. 6

TREM2 expression is decreased in AIS patients with high-salt intake and is correlated with the proinflammatory property of circulating monocytes and detrimental stroke outcomes. AIS patient dietary salt intake was measured with a 24-h urine sodium (24h UNa) with a normal limit of 170 mmol. a Representative images of the MRI-DWI of AIS patients with normal or high urine sodium concentration. Comparison of infarct size of AIS patients with normal (N = 13) or high (N = 25) urine sodium concentration. *P < 0.05 by Student’s t test. b Comparison of 1-day NIHSS, 7-day NIHSS of AIS patients with normal (N = 13) or high (N = 25) urine sodium concentration. *P < 0.05 by Student’s t test. c Heat map showing TREM2, CD206, and CD80 protein expression in peripheral monocytes of AIS patients with normal (N = 13) or high (N = 25) urine sodium concentration using flow cytometry. The function of “scale” was applied for value normalization. d Comparison of CD206 and CD80 protein expression in peripheral monocytes of AIS patients with normal (N = 13) or high urine sodium concentration (N = 25) using flow cytometry. *P < 0.05 by Student’s t test. e Comparison of TREM2 protein expression in peripheral monocytes of AIS patients with normal (N = 13) or high urine sodium concentration (N = 25) using flow cytometry. *P < 0.05 by Student’s t test. f Comparison of TREM2 mRNA expression in PBMCs of AIS patients with normal (N = 6) or high urine sodium concentration (N = 12). *P < 0.05 by Student’s t test. g Correlation of clinic parameters, the protein expression of TREM2 and 24h UNa was assessed with Spearman correlation analysis. *P < 0.05, **P < 0.01. DWI diffusion-weighted imaging, DM diabetes mellitus, HL hyperlipidemia, CHD coronary heart disease, AF atrial fibrillation, WBC white blood cell, NLR neutrophil-to-lymphocyte ratio, BNa blood sodium, CRP C-reactive protein, HCY homocysteine, and Hba1c glycated hemoglobin