Skip to main content
Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: STEAP4 expression in CNS resident cells promotes Th17 cell-induced autoimmune encephalomyelitis

Fig. 4

STEAP4 in neuroectoderm-derived cells is critical for actively-induced EAE. a Immunoblot analysis for STEAP4 expression in astrocytes from Nestin-Cre STEAP4fl/+ and Nestin-Cre STEAP4fl/fl mice. Astrocytes were cultured from brains of neonatal pups. b EAE incidence in Nestin-Cre STEAP4fl/+ and Nestin-Cre STEAP4fl/fl mice induced by active immunization with MOG35-55. c Mean clinical score of EAE in Nestin-Cre STEAP4fl/+ and Nestin-Cre STEAP4fl/fl mice induced by active immunization with MOG35–55 peptides. d H&E, anti-CD4, and MBP staining of spinal cords from Nestin-Cre STEAP4fl/+ and Nestin-Cre STEAP4fl/fl mice 22 days after EAE induction. e Absolute cell numbers of infiltrated immune cells in the brains of Nestin-Cre STEAP4fl/+ and Nestin-Cre STEAP4fl/fl mice 22 days after immunization. Data are representative of three independent experiments. n = 5/group in each experiment. Error bars, SEM; *p < 0.05

Back to article page