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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Inhibiting BDNF/TrkB.T1 receptor improves resiniferatoxin-induced postherpetic neuralgia through decreasing ASIC3 signaling in dorsal root ganglia

Fig. 1

RTX injection increased ASIC3 and TrkB.T1 expression in DRGs. a Paw withdrawal thresholds (n = 10, *P < 0.05, **P < 0.01, two-way repeated measures ANOVA followed by Bonferroni’s post hoc test). b Paw withdrawal latency (n = 10, *P < 0.05, **P < 0.01, two-way repeated measures ANOVA followed by Bonferroni’s post hoc test). c Increased ASIC3 and TrkB.T1 mRNA expression after RTX injection (n = 4, *p < 0.05 vs. vehicle, Student’s t-test). d–f ASIC3 and TrkB.T1 protein expression in DRGs (n = 4, *p < 0.05 vs. vehicle, Student’s t-test). g–i TrkB.FL and p-TrkB.FL protein expression in DRGs (n = 4). g Merged double labeling of TrkB.T1 and ASIC3 (scale bar = 100 μm). h The percentage of ASIC3 labeled in TrkB.T1 positive cells (n = 5, *p < 0.05 vs. vehicle, Student’s t-test)

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