Fig. 3

Inhibition of ASIC3 decreased hyperexcitability in DRGs neurons. a Amiloride reduced RP of DRG neurons. b Amiloride increased rheobase of DRG neurons. c, d Amiloride reversed numbers of APs in response to 2× and 3× rheobase current stimulation. e–g Amiloride reduced numbers of APs evoked by 100-, 300-, and 500-pA ramp current stimulation. n = 11, *p < 0.05, **p < 0.01, vs. vehicle group; ^#p < 0.05, ^##p < 0.01 vs. RTX-PHN; one-way ANOVA followed by Tukey’s post hoc test)