Fig. 5

Inhibition of TrkB.T1 reduced hyperexcitability in DRGs neurons. a ANA-12 decreased RP of DRG neurons. b ANA-12 increased rheobase of DRG neurons. c, d ANA-12 reversed numbers of APs in response to 2× and 3× rheobase current stimulation. e–g ANA-12 reduced numbers of APs evoked by 100-, 300- and 500-pA ramp current stimulation. n = 12, *p < 0.05, **p < 0.01 vs. vehicle, ^#p <0.05, ^##p < 0.01 vs. RTX-PHN; one-way ANOVA followed by Tukey’s post hoc test