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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Suppression of neuroinflammation by an allosteric agonist and positive allosteric modulator of the α7 nicotinic acetylcholine receptor GAT107

Fig. 1

Amelioration of the clinical course of EAE on treatment with the ago-PAM GAT107. EAE was induced in wild-type (WT) mice by immunization with myelin oligodendrocyte glycoprotein (MOG)35–55. The animals were given either placebo or GAT107 (10 mg/kg) twice daily by intraperitoneal injection. The results are expressed as the mean clinical score ± standard error (SE) of data from four separate experiments (n = 29 in the placebo group and n = 24 in GAT107-treated group) (**p < 0.001)

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Journal of Neuroinflammation

ISSN: 1742-2094