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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Suppression of neuroinflammation by an allosteric agonist and positive allosteric modulator of the α7 nicotinic acetylcholine receptor GAT107

Fig. 7

Suppressive effect of GAT107 on inflammatory cytokine release from PBMCs from HDs and MS patients. PBMCs were purified from samples from human donors, including healthy donors (a, b) and MS patients (c, d), and stimulated with ConA (5 μg/ml) with and without ACh (100 μM) or GAT107 (10 μM) for 24 h. (a + c) IL-17 and (b + d) IL-6 secretion were detected by ELISA (n = 17–19) (*p < 0.05)

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Journal of Neuroinflammation

ISSN: 1742-2094