Fig. 3
From: Orthopedic surgery-induced cognitive dysfunction is mediated by CX3CL1/R1 signaling
The level of pro-inflammatory cytokines and mRNA expression in POCD mice. a IL-1β, IL-6, and TNF-α in the prefrontal cortex, the hippocampus, and the amygdala at different time points after tibial fracture surgery (one-way ANOVA with Tukey’s post hoc, n = 8~11 per group). b The mRNA level of CX3CR1 in the prefrontal cortex, the hippocampus, and the amygdala at different time points after tibial fracture surgery (one-way ANOVA with Tukey’s post hoc, n = 4~5 per group). Control, normal control group; TF, tibial fracture surgery group; 2hr, 2 h after surgery; 6hr, 6 h after surgery; 24hr, 1 day after surgery; 2D, 2 days after surgery; 5D, 5 days after surgery; *p < 0.05 compared to the control