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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Orthopedic surgery-induced cognitive dysfunction is mediated by CX3CL1/R1 signaling

Fig. 5

Anti-inflammatory effect of inhibition of CX3CR1 signaling in tibial fracture-induced POCD mice. The levels of the pro-inflammatory cytokines TNF-α, IL-6, and IL-1β in the prefrontal cortex, the hippocampus, and the amygdala (one-way ANOVA with Tukey’s post hoc, n = 3~10 per group). Control, normal control group; TF2D, 2 days after tibial fracture surgery group; TF+Ab, 2 days after tibial fracture surgery group injected with neutralizing Ab; Control+Ab, normal control group injected with neutralizing Ab. *p < 0.05; **p < 0.01; ***p < 0.0001 compared to the control; #p < 0.05; ##p < 0.01; ###p < 0.0001 compared to TF2D

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