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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Conditional knockout of Tsc1 in RORγt-expressing cells induces brain damage and early death in mice

Fig. 4

Tsc1RORγt mice exhibited spontaneous tonic-clonic seizures with neuronal defects. a Representative images of spontaneous generalized tonic-clonic seizures at different phases observed in the Tsc1RORγt mice. These images were extracted from a video of Tsc1RORγt mice housed with control littermates. b The brain weights of Tsc1RORγt mice and control littermates. c Representative images of HE staining and thickness of the cortex of the brains of Tsc1RORγt mice and control littermates. d, e Representative HE staining images of the cortex (d) and hippocampus (e) of Tsc1RORγt mice and control littermates. f Representative images of NeuN immunostaining (red) and the cell scattering width in the CA and DG regions of the hippocampus from Tsc1RORγt mice and control littermates. Each dot represents one mouse, and error bars represent SEMs; *p < 0.05, **p < 0.01. Unpaired two-tailed Student’s t test (b, c, f). All images were captured from scans of whole-brain slices. Magnification: × 10 (c), × 20 (upper panels in d, e), and × 40 (lower panels in d, e, f). Scale bars: 50 μm (d, e, f) and 100 μm (c)

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