Fig. 6
From: Conditional knockout of Tsc1 in RORγt-expressing cells induces brain damage and early death in mice
Defects in the GABA signalling pathway are at least partially responsible for seizures and death in Tsc1RORγt mice. a Relative mRNA expression of GABA receptor subunit genes, neural cadherin-like cell adhesion genes, voltage-gated channel genes, and other genes related to neuronal function in the whole brains of Tsc1RORγt mice and control littermates. b, c Seizure latency (b) and survival rate (c) of Tsc1RORγt mice and control littermates after PTZ administration. d, e Survival rate (d) and longevity (e) of Tsc1RORγt mice, Tsc1RORγt mice supplemented with GABA and control littermates. Each dot represents one mouse, and error bars represent SEMs; *p < 0.05, **p < 0.01, and ***p < 0.001. n = 4–7 (c) and n = 7–14 (d, e). Unpaired two-tailed Student’s t test (a–c, e). One-way ANOVA (d)