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Fig. 1. | Journal of Neuroinflammation

Fig. 1.

From: Oxidative stress induced by NOX2 contributes to neuropathic pain via plasma membrane translocation of PKCε in rat dorsal root ganglion neurons

Fig. 1.

SNI induces NOX2 upregulation in DRG neurons. a Paw withdrawal threshold (PWT) after SNI (n = 5–6/group). Mann–Whitney U test. *p < 0.05, **p < 0.01 versus the sham group. b NOX2 expression in L4–L6 DRGs from rats in (a) at 1, 7, and 14 days after SNI and sham surgery was determined by Western blotting (n = 4/group). n.s. indicates not significant. One-way ANOVA followed by Tukey’s test. *p < 0.05 versus the sham group. c Representative double-immunofluorescence staining showing the colocalization of NOX2 with IB4 (c(a)), CGRP (c(b)), NF-200 (c(c)), and CD11b (c(d)) but not GFAP (c(e)) at day 7 after SNI. c(f) The histogram shows the percentage of NOX2-positive cells among the various cell markers (n = 6/group)

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