Fig. 7
Oxidative stress induces mechanical allodynia via the plasma membrane translocation of PKCε. a Effects of PBN and catalase on the 50% PWT after drug application. The dotted arrow indicates the time of PBN, catalase, or vehicle application (n = 5–6/group). Kruskal-Wallis test followed by Dunn’s multiple comparison test. *p < 0.05, **p < 0.01, ***p < 0.001 versus the sham group. b, c Treatment with PBN or catalase 1 day after SNI inhibited the upregulation of PKCε protein expression in both the plasma membrane (b) and cytosol (c) of DRGs (n = 6/group). One-way ANOVA followed by Tukey’s test. **p < 0.01 versus the vehicle-treated sham group; #p < 0.05, ##p < 0.01 versus the vehicle-treated SNI group. d εV1-2 reversed H2O2-induced mechanical allodynia (n = 6/group). Mann-Whitney U test. **p < 0.01 versus the vehicle-treated H2O2 group