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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: IL-9-triggered lncRNA Gm13568 regulates Notch1 in astrocytes through interaction with CBP/P300: contribute to the pathogenesis of experimental autoimmune encephalomyelitis

Fig. 6

LncRNA Gm13568 interacts with CBP/P300 to regulate the expression of Notch1 in astrocytes. a RIP assay was performed for the interaction of Gm13568 with NF-κB p65 and CBP/P300 in astrocytes treatment with IL-9 for 6 h. The data were from three independent experiments. b ChIP assay analysis of NF-κB p65, CBP/P300, RNA Pol II, and H3K27ac enrichment on the promoter of Notch1 gene in astrocytes stimulation with IL-9 for 6 h. *p < 0.05, **p < 0.01, ***p < 0.001 vs DMEM (one-way ANOVA). The data are from three independent experiments. Error bars represent mean ± SEM. c ChIP assay analysis of NF-κB p65, CBP/P300, and H3K27ac enrichment on the promoter of Notch1 gene in astrocytes infected by LV-Inhibit-Gm13568 for 72 h, followed by stimulation with IL-9 for 6 h. #p < 0.05 versus LV-ctrl. The data were from three independent experiments

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Journal of Neuroinflammation

ISSN: 1742-2094