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Fig. 9 | Journal of Neuroinflammation

Fig. 9

From: IL-9-triggered lncRNA Gm13568 regulates Notch1 in astrocytes through interaction with CBP/P300: contribute to the pathogenesis of experimental autoimmune encephalomyelitis

Fig. 9

Schematic representation of lncRNA Gm13568 contributing to the pathogenesis of EAE mice via regulation of the Notch1 pathway. Under IL-9 stimulation, Gm13568 is upregulated in astrocytes, which promotes the expression and activation of Notch1 via interacting with CBP/P300, in turn contributing to the release of inflammatory cytokines, thus aggravating the EAE development

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Journal of Neuroinflammation

ISSN: 1742-2094