Table 1 Demographic and main clinical characteristics of pediatric and adult cohorts

Age at initial manifestation, median (range)

10.5 (4–15)

35.0 (19–64)

<0.001

Females, n (%)

13 (65.0%)

20 (51.3%)

0.157

Ethnicity

20 Caucasians

36 Caucasians

3 Asians

0.081

Disease duration (years), median (range)

4.5 (0–22)

6.5 (0–24)

0.084

Patients with a clinical history of ON, n (%)

18 (90.0%)

24 (61.5%)

0.001

Patients with unilateral ON, n (%)

6 (30.0%)

6 (15.4%)

0.062

Patients with bilateral ON, n (%)

12 (60.0%)

18 (46.2%)

0.154

Patients with a simultaneous bilateral ON, n (%)

8 (40.0%)

14 (35.9%)

0.663

Total ON eyes, n (%)

30 (75.0%)

42 (53.8%)

0.029

Number of ON episodes per eye, mean (SD)

1.8 (1.3)

2.0 (1.7)

0.864

Time between ON and examination in months, median (range)

7 (6–129)

10 (6–155)

0.2