Fig. 4
From: Capsazepine decreases corneal pain syndrome in severe dry eye disease
Responsiveness of corneal polymodal nociceptive fibers to CO2 stimulation for sham and DED animals. a, b Electrophysiological traces and histograms illustrating corneal responsiveness to a 30-s CO2 pulse. c Histogram showing the latency of impulse discharge evoked by CO2 for sham and DED animals. Total number of mice = 16. Number of mice included in the analysis =16. Sham and DED animals: n = 8 per group. All experiments were conducted on d21. **P < 0.01 relative to sham group. Results are expressed as the mean ± SEM. For statistical analysis, the Kolmogorov–Smirnov test was performed followed by a parametric t-test using GraphPad Prism version 7.00 (GraphPad Software, La Jolla, CA, USA)