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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: High-fat diet impairs duodenal barrier function and elicits glia-dependent changes along the gut-brain axis that are required for anxiogenic and depressive-like behaviors

Fig. 6

Schematic model of the gut-brain signaling during metabolic diseases and related behavioral disorders. Chronic exposure to high-fat diet (HFD) alters intestinal physiology, inducing a low-grade inflammation, dysbiosis, and increased mucosal permeability. Microbe-derived products that violate the impaired intestinal barrier may activate enteric glia within the enteric nervous system (ENS) via TLR4 pathway, leading to reactive gliosis and ENS neurons dysfunction. This elicits a glia-dependent signaling between the gastrointestinal tract and the brain responsible for impairing the energy metabolism and behavior, including depressive- and anxiety-like symptoms

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Journal of Neuroinflammation

ISSN: 1742-2094