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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: miR-155 and miR-146a collectively regulate meningitic Escherichia coli infection-mediated neuroinflammatory responses

Fig. 8

Antagomir-155 and antagomir-146a promote the production of inflammatory cytokines and chemokines in the E. coli infected mice. Mice were injected with antagomir-155, antagomir-146a, or antagomir-ctrl 24 h before PCN033 challenge. At 6 h post-challenge, the brain tissues were collected. a and b qPCR analysis of the expression of miR-155 and miR-146a from brain tissues (n = 5–6/group). Data represented the mean ± SD. Statistical analysis was carried out by one-way ANOVA. c Bacterial loads in the blood and brain from three groups of mice were compared. d qPCR analysis of IL-1β, IL-6, TNF-α, MCP-1, and MIP-2 in brain tissues. e ECL analysis of IL-1β, IL-6, TNF-α, MCP-1, and MIP-2 in brain tissues. Data represented the mean ± SD. Statistical analysis was carried out by one-way ANOVA. p < 0.05 was considered statistically significant; p < 0.01 and p < 0.001 indicated extremely significant differences

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