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Fig. 9 | Journal of Neuroinflammation

Fig. 9

From: miR-155 and miR-146a collectively regulate meningitic Escherichia coli infection-mediated neuroinflammatory responses

Fig. 9

Antagomir-155 and antagomir-146a aggravate neuroinflammation and reduce survival duration in the E. coli-infected mice. a H&E staining of brain sections. The scale bar indicated 50 μm. b and c Immunofluorescence analysis of GFAP and IBA1 in brain sections; the scale bar indicated 100 μm. d. Quantification of the mean fluorescence intensity of GFAP- and IBA1-positive cells in the brain. Data represented the mean + SD. Statistical analysis was carried out by one-way ANOVA. e Survival of mice in each group was monitored for 24 h after tail vein injection of PCN033. Data were collected and shown as Kaplan–Meier survival curves (n = 10). Statistical analysis was carried out by Log–rank (Mantel-Cox) test. p < 0.05 was considered statistically significant; p < 0.01 and p < 0.001 indicated extremely significant differences

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