Fig. 3
Aβ1-42 and fibrillar Aβ in the cortex PtA and hippocampus in groups of mice. a Representative images showed Aβ1-42 staining in the cortex PtA and hippocampus subregions. b Quantification of Aβ1-42 immunopositivity in the cortex and hippocampus of mice. The data are presented as mean ± SEM (n = 4/group) in the different experimental groups. c Representative merged images showed Aβ plaque stained by Thioflavin S in the cortex. d Quantification of Aβ plaque number and diameter in the cortex. The data are presented as mean ± SEM (n = 3/group) in the different experimental groups. e The protein levels of Aβ degrading enzymes IDE and MME in the cortex and hippocampus were measured by western blotting. The measurement of gray intensity of IDE f and MME g in the cortex and hippocampus. The data are presented as mean ± SEM (n = 5/group) in the different experimental groups. h Aβ1-42 in tissue lysis of cortex and hippocampus using ELISA detection. The data are presented as mean ± SEM (n = 4/group) in the different experimental groups. #p < 0.05, ##p < 0.01, ###p < 0.001 vs WT mice; *p < 0.05, **p < 0.01 vs APP/PS1 mice; ^p < 0.05 vs APP/PS1 + Tβ4 mice