Fig. 7

Brain cytokine expression, Aβ pathology, and tau deposition in non-demented individuals with cerebral Aβ pathology. The average fold change of inflammatory molecule expression per brain region was calculated. Briefly, NCI individuals with Aβ deposition displayed an increase in IL-1β (~ 1.8 fold change), IL-6 (~ 3.4 fold change), and eotaxin-3 (~ 3 fold change) in the temporal cortex; an increase in IL-1β (~ 2 fold change) and MCP-1 (~ 1.8 fold change) in the parietal cortex; and similar trends revealing higher levels of IL-1β (~ 1.5 fold change), IL-6 (~ 1.8 fold change), and MCP-1 (~ 1.7 fold change) in the frontal cortex as compared with individuals without Aβ deposition. Tau pathology was highest in the temporal cortex as compared with the parietal and frontal cortices from Aβ+ individuals. Individuals with Aβ pathology also showed cognitive deficits in perceptual speed