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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Phthalide derivative CD21 attenuates tissue plasminogen activator-induced hemorrhagic transformation in ischemic stroke by enhancing macrophage scavenger receptor 1-mediated DAMP (peroxiredoxin 1) clearance

Fig. 1

CD21 protected against ischemic brain injury and hemorrhagic transformation in tPA-infused tMCAO mice. a Chemical structure of CD21. b Overall experimental design. c, d mNSS and Corner test scores. e, f Representative images and statistical analysis of infarct volume by TTC staining. g, h Representative images of the hemorrhagic brain and statistical analysis of hemorrhagic volume in the ipsilateral brain hemisphere. The data are expressed as mean ± SD (n = 10/group in c and d, n = 5/group in e–h). #p < 0.05, ##p < 0.01, vs. tMCAO group; **p < 0.01, vs. tPA group

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Journal of Neuroinflammation

ISSN: 1742-2094