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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Phthalide derivative CD21 attenuates tissue plasminogen activator-induced hemorrhagic transformation in ischemic stroke by enhancing macrophage scavenger receptor 1-mediated DAMP (peroxiredoxin 1) clearance

Fig. 2

CD21 ameliorated blood-brain barrier disruption in tPA-infused tMCAO mice. a Representative images and statistical analysis of Evans blue extravasation in the ipsilateral brain hemisphere. b, c Representative immunoblots and quantitative analysis of tight junction proteins (ZO-1 and claudin-5) in the ipsilateral brain hemisphere. d Representative images of MMP-9 and CD31 double immunostaining surrounding cerebral vessels in the peri-infarct area. e Quantification of MMP-9 fluorescence intensity (FI) surrounding cerebral vessels in the peri-infarct area. f Representative zymography and quantification of MMP-9 activity in the ipsilateral brain hemisphere. The data are expressed as mean ± SD (n = 4/group in a–c and f, n = 5/group in d and e). #p < 0.05, ##p < 0.01, vs. tMCAO group; *p < 0.05, **p < 0.01, vs. tPA group

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Journal of Neuroinflammation

ISSN: 1742-2094