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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Phthalide derivative CD21 attenuates tissue plasminogen activator-induced hemorrhagic transformation in ischemic stroke by enhancing macrophage scavenger receptor 1-mediated DAMP (peroxiredoxin 1) clearance

Fig. 4

CD21 decreased extracellular Prx1 in the ischemic brain in tPA-infused tMCAO mice. a Representative photomicrographs of Prx1 immunoreactivity, TUNEL-positive apoptotic cells, and pan-cadherin-positive cell membrane in the peri-infarct area. b–e Representative Western blots and quantitative analysis of Prx1, MAFB, and MSR1 expression in the ipsilateral brain hemisphere. Scalebar (a) = 25 μm. The data are expressed as mean ± SD (n = 4/group). #p < 0.05, ##p < 0.01, vs. tMCAO group; *p < 0.05, **p < 0.01, vs. tPA group

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Journal of Neuroinflammation

ISSN: 1742-2094