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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Phthalide derivative CD21 attenuates tissue plasminogen activator-induced hemorrhagic transformation in ischemic stroke by enhancing macrophage scavenger receptor 1-mediated DAMP (peroxiredoxin 1) clearance

Fig. 7

Schematic representation of the protective effect of CD21 against tPA-induced HT in acute ischemic stroke. CD21 increased MSR1 expression in M2 microglia/macrophages and MSR1-related lysosomal clearance of the DAMP Prx1, thereby ameliorating tPA-induced HT through inhibition of the DAMP (Prx1)/TLR4/NF-κB pathway and neuroinflammation and attenuation of BBB dysfunction in acute ischemic stroke

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Journal of Neuroinflammation

ISSN: 1742-2094