Brain gray matter astroglia-specific connexin 43 ablation attenuates spinal cord inflammatory demyelination

Table 2 Comparison of astroglial gene expression among the pre-immunized, onset, and peak phases of EAE in Cx43 icKO and Cx43^fl/fl mice

Gene cluster	Pre vs. Onset		Pre vs. Peak		Onset vs. Peak
Gene cluster	Cx43 fl/fl	Cx43 icKO	Cx43 fl/fl	Cx43 icKO	Cx43 fl/fl	Cx43 icKO
A1 (Pro-inflammatory)	0.038* (Onset)	NS	0.004 (Peak)	< 0.001 (Peak)	NS	NS
A2 (Anti-inflammatory)	0.011 (Onset)	NS	NS	0.010 (Peak)	0.024 (Onset)	NS
Pan-reactive	0.0016 (Onset)	NS	0.008 (Peak)	0.057 (Peak)	NS	0.025 (Peak)

A disease phase showing significantly higher levels of the relevant gene expression than their comparators is indicated in parentheses. Onset is dpi 10 and Peak is dpi 17
Cx connexin, dpi days post-immunization, EAE experimental autoimmune encephalomyelitis, ES enrichment score, fl flox, icKO inducible conditional knock-out, NS not significant, Pre pre-immunized
*P values of the ES plots are shown

ISSN: 1742-2094