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Table 3 Comparison of astroglial gene expression between Cx43fl/fl and Cx43 icKO mice in the pre-immunized, onset, and peak phases of EAE

From: Brain gray matter astroglia-specific connexin 43 ablation attenuates spinal cord inflammatory demyelination

Gene cluster

Cx43 fl/fl vs. Cx43 icKO

Pre-immunized

Onset

Peak

A1 (Pro-inflammatory)

NS

0.018 (fl/fl)

NS

A2 (Anti-inflammatory)

< 0.001 (icKO)

NS

NS

Pan-reactive

0.0018 (icKO)

0.0017 (fl/fl)

NS

  1. Mouse genotypes showing significantly higher levels of the relevant gene expression than their comparators are indicated in parentheses. Onset is dpi 10 and Peak is dpi 17
  2. Cx connexin, dpi days post-immunization, EAE experimental autoimmune encephalomyelitis, ES enrichment score, fl flox, icKO inducible conditional knock-out
  3. *P values of the ES plots are shown