Gene cluster | Cx43 fl/fl vs. Cx43 icKO |
---|
Pre-immunized | Onset | Peak |
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A1 (Pro-inflammatory) | NS | 0.018 (fl/fl) | NS |
A2 (Anti-inflammatory) | < 0.001 (icKO) | NS | NS |
Pan-reactive | 0.0018 (icKO) | 0.0017 (fl/fl) | NS |
- Mouse genotypes showing significantly higher levels of the relevant gene expression than their comparators are indicated in parentheses. Onset is dpi 10 and Peak is dpi 17
- Cx connexin, dpi days post-immunization, EAE experimental autoimmune encephalomyelitis, ES enrichment score, fl flox, icKO inducible conditional knock-out
- *P values of the ES plots are shown