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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Divanillyl sulfone suppresses NLRP3 inflammasome activation via inducing mitophagy to ameliorate chronic neuropathic pain in mice

Fig. 2

DS treatment improved sciatic nerve ligation-induced chronic neuropathic pain. Neuropathic pain mice were induced by ligation of sciatic nerve, the mechanical withdrawal threshold within 14 days after surgery (a) and intrathecal injection of vehicle (0.9% normal saline) or DS (1, 3, 10 mg/kg) 9 days after surgery (b) were measured by Von Frey Monofilament in both contralateral and ipsilateral paws. c The analgesic effects of both drugs over four consecutive days post-injection. d Dose-response analysis of DS on paw withdrawal threshold 0.5 h after administration, and ED50 was calculated with GraphPad Prism 8 with normalized to maximal possible effect. Data are expressed as means ± SEM (n = 8 mice in each group). Statistical significance was determined by two-way ANOVA followed by Tukey’s post hoc analysis where *P < 0.05, **P < 0.01, ***P < 0.001 vs. CCI + Saline group, ***P < 0.001 vs. Sham-ipsilateral paw group

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