Fig. 6
IL-1β neutralizing antibody enhanced heat intolerance induced by heat stroke. Two dosages of 0.04 μg/g and 0.2 μg/g IL-1β neutralizing antibody were injected intravenously 30 min before heat stroke. Saline was involved in the control. a Survival curve was monitored in comparison between saline and IL-1β neutralizing antibody groups. The statistical analysis was conducted by Log-rank test (n = 20), **p < 0.01, *p < 0.05. b Core temperature (TC) profiles of mice were monitored in every 15 min to compare saline and IL-1β neutralizing antibody groups. The average time taken by core temperature to reach 42 °C was calculated as the mean ± SEM. (n = 5 to 10). **p < 0.01