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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Type I IFN signaling limits hemorrhage-like disease after infection with Japanese encephalitis virus through modulating a prerequisite infection of CD11b+Ly-6C+ monocytes

Fig. 2

IFN-I signal limits the pathological process in non-lymphoid and lymphoid peripheral tissues. a Histopathological examinations of the peripheral and CNS tissues in IFN-I signal-competent and -incompetent mice. Following JEV infection (5 × 106 ffu) via the footpad route, paraffin-embedded tissues including popliteal LNs (pLNs), spleen, mesenteric LNs (mLNs), liver, intestine, and brain were prepared on the 2nd day, and used for histological examinations with H&E staining. b Histopathological examinations of the CNS in IFN-I signal-competent mice showing neurological disorders following JEV infection. The arrows denote the area of interest. c Detection of JEV Ags in the non-lymphoid and lymphoid tissues in the periphery of IFN-I incompetent mice. d Detection of JEV Ags in the brain of both IFN-I signal-competent and -incompetent mice. e Detection of JEV Ags in the CNS in IFN-I signal-competent mice showing neurological disorders following JEV infection. Sections prepared from lymphoid and non-lymphoid tissues including pLNs, spleen, liver, intestine, and brain were used for the detection of JEV Ags (NS1 and E proteins). Images are representative of sections (200×) derived from at least four mice. Areas of interest infiltrated with leukocytes are denoted by black arrows

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