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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: miR-1224 contributes to ischemic stroke-mediated natural killer cell dysfunction by targeting Sp1 signaling

Fig. 4

miR-1224 negatively regulates NK cell function in the spleen by modulating Sp1. a Sp1 gene expression was analyzed by real-time PCR after miR-1224 inhibitor treatment in MCAO mice. b, c Heterozygous Sp1-knockout mice were used to explore the role of the Sp1 transcription factor in NK cell regulation by miR-1224. Flow cytometry shows the numbers and functional markers (CD69, IFN-γ) of NK (NK1.1+CD3−) cells from the spleens and brains of wild-type and Sp1−/− mice subjected to MCAO. Data are representative of three independent experiments. n = 3~11 mice per group. *p < 0.05, **p < 0.01 by two-way ANOVA. Error bars represent the mean ± SEM

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