Fig. 1

Effect of cordycepin on sensorimotor behavior, GMI and WMI. a Cylinder test, grid walking test, and wire-hanging test conducted for 7 days after TBI, and rotarod test up to 28 days after TBI. n=9/group. b Representative images of serial coronal sections labeled with MAP2 35 days after TBI. Scale bar: 1 mm. c The otal tissue loss volume and tissue loss area of each serial section. n=6~7/group. d Representative MBP/NF-200 stained images of the striatum 35 days after TBI. Scale bar: 50 μm. The location of the representative image was indicated with a red pane in the schematic picture. e Quantification of NF-200 fluorescence intensity, MBP fluorescence intensity, and percentage of bundles area in the striatum. n=6/group. f Representative transmission electron microscope images of the corpus callosum 35 days after TBI, blue arrows and red arrows indicate degenerating myelinated axons and nonmyelinated axons, respectively. Scale bar: 500 nm. g Quantification of the g-Ratio of myelinated axons (inner diameter/outside diameter). h Quantification of the numbers of nonmyelinated axons and degenerating nonmyelinated axons. n=4/group. Random 100 axons of each mouse were focused for g-Ratio statistics. i Representative CAPs and quantification of N2 amplitude. n=6/group. veh (vehicle), COR (cordycepin), ^#p < 0.05, ^##p < 0.01, and ^###p < 0.001, or *p < 0.05, **p < 0.01, and ***p < 0.001 as indicated