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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Anti-CD20 treatment effectively attenuates cortical pathology in a rat model of widespread cortical demyelination

Fig. 4

Representative immunofluorescent stainings comparing the therapy groups, control groups, and C0. Because of the comparability of the different experimental approaches, only C2/E2 results are shown side by side for comparison to avoid redundancy and allow an easy overview. The first line shows Iba1 staining (marked in green), a marker for microglial activation. Microglial activation of C0 (a) is comparable to E2 (b), whereas C2 (c) shows more microglial activation. A similar pattern is detectable when looking at GFAP staining (marked in red), a marker for activated astrocytes in the second line. Also, C0 (d) and E2 (e) results are comparable and there are more activated astrocytes detectable in C2 (f). The neuronal preservation (red dots) in E2 (h) is comparable to neuron occurrence in naïve animals (g) in C2; however, neuronal loss is detectable (i). Scale bars represent 100 μm

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