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Fig. 11 | Journal of Neuroinflammation

Fig. 11

From: Aging and high-fat diet feeding lead to peripheral insulin resistance and sex-dependent changes in brain of mouse model of tau pathology THY-Tau22

Fig. 11

Western blots of hippocampal insulin signaling pathway markers of 11-month-old THY-Tau22 and wt mice. a Western blots for specific proteins. b Quantification of (a) western blots. Data are presented as mean ± SEM and were statistically analyzed by Mann-Whitney t test within each age and sex group (*p < 0.05; **p < 0.01; n = 6). Mouse wt group on St diet was set as 100 %. The intensity of all proteins was related to particular β-actin intensity. The intensity of phosphorylated protein was related to the total protein. pAkt, phosphorylated protein kinase B; pPDK-1 (S241), phosphoinositide-dependent kinase-1 phosphorylated at S241 residue; pGSK-3β, glycogen synthase kinase 3β phosphorylated at S9 residue; PI3Kp85, p85 regulatory subunit of phosphoinositide 3-kinase

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