Fig. 9

Fluorescence-labeled THY-Tau22 and wt mouse brains. Colocalization of cell nuclei (blue DAPI), pTau (T231) (green AT180), and activated astrocytes (red GFAP). The representative figures of right hemisphere brain sections of a 7-month-old wt male mouse (upper pictures series) and THY-Tau22 mouse (lower pictures series), both on St diet, and b 11-month-old wt male mouse (upper pictures series) and THY-Tau22 male mouse (lower pictures series), both on HF diet, stained with particular fluorescence antibodies. White- and orange-framed inserts in left down and up right corners show magnified areas in particular color frames. Scale bar for whole brain section 500 μm, for inserts 200 μm. GFAP glial fibrillary acidic protein, DAPI 4′,6-diamidin-2-fenylindol