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Table 5 Metabolic parameters of THY-Tau22 and wt mice. Three-month-old

From: Aging and high-fat diet feeding lead to peripheral insulin resistance and sex-dependent changes in brain of mouse model of tau pathology THY-Tau22

Parameter

Sex

wt St

Tau22 St

Fasting glucose [mmol/l] (n = 4–5)

Male

6.32±0.30

5.93±0.36

Cholesterol [mmol/l] (n = 4–5)

Male

1.24±0.07

1.20±0.06

FFA [ng/ml] (n = 4–5)

Male

0.24±0.08

0.34±0.06

TG [mmol/l] (n = 4–5)

Male

0.22±0.05

0.30±0.04

Leptin [ng/ml] (n = 4–5)

Male

0.59±0.06

0.51±0.03

Fasting glucose [mmol/l] (n = 4–5)

Female

5.30±0.43

4.00±0.28+

Cholesterol [mmol/l] (n = 4–5)

Female

0.97±0.09

1.01±0.08

FFA [ng/ml] (n = 4–5)

Female

0.10±0.02

0.61±0.09+

TG [mmol/l] (n = 4–5)

Female

0.25±0.04

0.25±0.03

Leptin [ng/ml] (n = 4–5)

Female

0.52±0.08

0.87±0.18

  1. Fasting glucose, cholesterol, triglycerides (TG), free fatty acids (FFA), and leptin were measured in 3-, 7-, and 11-month-old males and females of both diets. The data are presented as mean ± SEM and were statistically analyzed by Mann-Whitney t test within each age and sex group (*HF vs St within the wt or Tau22 group, +Tau22 vs wt on the same diet). The age comparison was performed using mixed-effects analysis and Bonferroni’s post hoc test (#7 or 11 vs 3 months, $11 vs 7 months). Statistical significance for all measurements: *p < 0.05; **p < 0.01; ***p < 0.001