Skip to main content

Table 8 Insulin concentration and HOMA-IR and QUICKI indexes as insulin resistance quantification of THY-Tau22 and wt mice

From: Aging and high-fat diet feeding lead to peripheral insulin resistance and sex-dependent changes in brain of mouse model of tau pathology THY-Tau22

 

Sex

Age [months]

wt St

wt HF

Tau22 St

Tau22 HF

Fasting insulin [ng/ml]

Male (n = 7–8)

7

0.18±0.02

1.07±0.43**

0.15±0.03

1.17±0.32***

Male (n = 7–12)

11

0.40±0.11$

7.80±3.96**, $

0.15±0.05

2.43±0.85***

Female (n = 7–8)

7

0.17±0.03

0.57±0.14**

0.12±0.03

0.35±0.06**

Female (n = 6–7)

11

0.15±0.07

1.87±0.82**

0.22±0.06

3.58±1.57**, $$

HOMA-IR

Male (n = 7–8)

7

12.45±1.65

89.43±36.83***

10.81±2.83

102.47±32.20**

Male (n = 7–12)

11

23.66±6.00

475.67±210.86**, $

8.53±2.85

150.95±47.97***

Female (n = 7–8)

7

10.22±2.37

41.69±9.68**

7.36±1.86

26.52±4.33**

Female (n = 6–7)

11

9.08±4.12

83.87±32.06**

14.16±4.31

229.88±106.68**, $$

QUICKI

Male (n = 7–8)

7

0.35±0.01

0.29±0.01***

0.38±0.02

0.28±0.01**

Male (n = 7–12)

11

0.35±0.02

0.25±0.01**

0.39±0.01

0.27±0.01***

Female (n = 7–8)

7

0.37±0.01

0.31±0.01**

0.40±0.02

0.32±0.01**

Female (n = 6–7)

11

0.55±0.12$

0.29±0.01**

0.36±0.02

0.25±0.02**

  1. Fasting insulin was measured in 7- and 11-month-old males and females of both diets. HOMA-IR and QUICKI indexes [23, 24] were calculated from the fasting insulin and fasting glucose concentrations (Table 5) for 7- and 11-month-old mouse groups. The data are presented as mean ± SEM and were statistically analyzed by Mann-Whitney t test within each age and sex group (*HF vs St within the wt or Tau22 group). The age comparison was performed using mixed-effects analysis and Bonferroni’s post hoc test ($11 vs 7 months). Statistical significance for all measurements: *p < 0.05; **p < 0.01; ***p < 0.001. HOMA-IR homeostatic model assessment for insulin resistance, QUICKI quantitative insulin sensitivity check index