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Fig. 9 | Journal of Neuroinflammation

Fig. 9

From: Microglia RAGE exacerbates the progression of neurodegeneration within the SOD1G93A murine model of amyotrophic lateral sclerosis in a sex-dependent manner

Fig. 9

Reactive A1 astrocytes are reduced in male SOD1G93A mice by microglia Ager deletion. a Representative images of GFAP and AMIGO2 staining in the lumbar spinal cord ventral horn of the indicated mouse groups. b Quantification of GFAP+ area. c Quantification of GFAP+ and AMIGO2+ overlap area. Mean ± SD. N = 7 SOD1G93A Agerfl/fl Cx3cr1Cre/+ mice, and N = 9 SOD1G93A Ager+/+ Cx3cr1Cre/+ mice. Independent two sample two-sided t test. In b, *p = 0.0132. In c, **p = 0.0076

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