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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: GPR110 ligands reduce chronic optic tract gliosis and visual deficit following repetitive mild traumatic brain injury in mice

Fig. 5

GPR110-dependent attenuation of rCHIMERA-induced chronic gliosis by synaptamide and A8. A, C. Representative immune-fluorescence micrographic images of Iba-1 (A) and GFAP (C) in the optic tract from WT and GPR110 KO mice at 3.5 months after injury (rCHI). WT and GPR110 KO mice were injected with A8 (1 mg/kg, i.p.) or synaptamide (5 mg/kg, i.p.) after each CHIMERA, and brains were collected for immunostaining at 3.5 months after the last injury. B, D Quantitative analysis showing significant suppression of Iba-1 (B) and GFAP expression (D) by the treatment with synaptamide or A8 compared to the vehicle-treated group (rCHI + V) in WT but not in GPR110 KO mice after rCHIMERA. The optic tract region (OT) is outlined with dashed lines. The data are expressed as mean ± SEM (n = 3). **p < 0.01, ****p < 0.0001 vs. Sham-WT

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