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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: GPR110 ligands reduce chronic optic tract gliosis and visual deficit following repetitive mild traumatic brain injury in mice

Fig. 6

GPR110-dependent decrease in chronic axonal damage after treatment with synaptamide or A8. A Representative micrographic images of silver-stained axons in the optic tract from WT and GPR110 KO mice. WT and GPR110 KO mice were injected with synaptamide (5 mg/kg, i.p.) or A8 (1 mg/kg, i.p.) after each CHIMERA, and brains were collected for silver staining at 3.5 months after the last injury. B Quantitative analysis showing significant suppression of silver staining in the optic tract by the treatment with synaptamide or A8 compared to the vehicle-treated group (rCHI + V) in WT but not in GPR110 KO mice after rCHIMERA. The optic tract region (OT) is outlined with dashed lines. The data are expressed as mean ± SEM (n = 4). ***p < 0.001, ****p < 0.0001 vs. Sham-WT

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