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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Traumatic brain injury results in unique microglial and astrocyte transcriptomes enriched for type I interferon response

Fig. 2

Microglia and astrocytes demonstrate sustained transcriptional activation following TBI, with far greater response seen in microglia. A Volcano plot showing the fold change of genes (log2 scale) between FPI and sham microglia and their significance. Genes included met criteria of adjusted p value < 0.1, log2FC > 0.6 from DESeq2 analysis. B Volcano plot showing the fold change of genes (log2 scale) between FPI and sham astrocytes and their significance. Genes included met criteria of adjusted p value < 0.1, log2FC > 0.6 from DESeq2 analysis. C Heatmap of top 25 differentially expressed genes by adjusted p value in microglia following FPI. D Heatmap of top 25 differentially expressed genes by adjusted p value in astrocytes following FPI. n=5 animals per condition

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Journal of Neuroinflammation

ISSN: 1742-2094