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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Red nucleus IL-33 facilitates the early development of mononeuropathic pain in male rats by inducing TNF-α through activating ERK, p38 MAPK, and JAK2/STAT3

Fig. 8

Red nucleus IL-33 facilitates the early development of mononeuropathic pain by inducing TNF-α through activating ERK, p38 MAPK and JAK2/STAT3 signaling pathways. A Western blotting showed that red nucleus TNF-α was increased at 1 week post-SNI, intrarubral injection of anti-IL-33 antibody at 1 week post-SNI suppressed the overexpression of TNF-α (n = 6 per group, F = 14.302, P < 0.001). B Western blotting displayed that intrarubral administration of PD98059, SB203580, or AG490 at 1 week post-SNI inhibited the production of TNF-α (n = 6 per group, F = 13.157, P < 0.001). C Immunohistochemistry showed that red nucleus TNF-α was upregulated at 1 week post-SNI, intrarubral injection of anti-IL-33 antibody, PD98059, SB203580, or AG490 at 1 week post-SNI suppressed the production of TNF-α (n = 4 per group, F = 33.029, P < 0.001). **P < 0.01 and ***P < 0.001. Scale bars = 50 μm

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