Fig. 4

Colitis increased Aβ accumulation in WT mice but not NLRP3 KO mice. A Representative images of Aβ1–40 fragment immunoexpression in the cortex (i) and hippocampus (ii) (Left 3 rows: 40× objective; right row: expanded images (3×) of regions in the white boxes). B Comparison of Aβ1–40 expression intensity in the cortex (i) and hippocampus (ii) among control WT, DSS-fed WT, NLRP3 KO, and DSS-fed NLRP3 KO mice. C Representative images of Aβ1–42 fragment immunoexpression and neurons in the cortex (i) and hippocampus (ii) (Left 3 rows: 40× objective; right row: expanded images (3×) of regions in the white boxes). D Comparison of Aβ1–42 expression intensity in the cortex and hippocampus among treatment groups. Each dataset is expressed as mean ± SD. *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001; ****P ≤ 0.0001. n = 6 mice