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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Chronic colitis exacerbates NLRP3-dependent neuroinflammation and cognitive impairment in middle-aged brain

Fig. 6

Colitis promoted transformation to the A1-like astrocyte phenotype in WT mice but not NLRP3 KO mice. A Representative images of C3 immunoexpression and astrocytes in the cortex (63× oil immersion objective). B Comparison of C3 immunofluorescence intensity (i) and C3-positive (A1-like) astrocyte number (ii) in the cortex among control WT, DSS-fed WT, NLRP3 KO, and DSS-fed NLRP3 KO mice. C Representative images of C3 immunoexpression and astrocytes in the hippocampus (63× oil immersion objective). D Comparison of C3 immunofluorescence intensity (i) and C3-positive (A1-like) astrocyte number (ii) in the hippocampus among treatment groups. Each dataset is expressed as mean ± SD. *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001; ****P ≤ 0.0001. n = 6 mice

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