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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Chronic colitis exacerbates NLRP3-dependent neuroinflammation and cognitive impairment in middle-aged brain

Fig. 7

Colitis impaired glymphatic clearance in WT mice but not NLRP3 KO mice. A Representative three-dimensional images at 5, 15, 30, 45, and 60 min after infusion of FITC-dextran into the cisterna magna (25× water immersion objective). B Linear (i) and histogram (ii and iii) analyses of overall FITC-dextran intensity at different time points after infusion among control WT, DSS-fed WT, control NLRP3 KO mice, and DSS-fed NLRP3 KO mice. C Representative two-dimensional images 100 μm below the cortical surface at 5, 15, 30, 45, and 60 min after infusion of FITC-dextran into the cisterna magna (25× water immersion objective). D Linear (i) and histogram (ii and iii) analyses of FITC-dextran intensity in the paravascular space at different time points among control WT, DSS-fed WT, control NLRP3 KO, and DSS-fed NLRP3 KO mice. Each dataset is expressed as mean ± SD. *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001; ****P ≤ 0.0001. n = 6 mice

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